Epitopes described in "Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide."

Reference
Article Authors:W M Kast; L Roux; J Curren; H J Blom; A C Voordouw; R H Meloen; D Kolakofsky; C J Melief
Article Title:Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.
Reference Detail
Reference ID:1003719
Abstract:The only peptide of Sendai virus that is recognized by cytotoxic T lymphocytes (CTL) in B6 mice was found with (i) the use of recombinant vaccinia virus constructs containing separate genes of Sendai virus and (ii) a set of overlapping peptides completely spanning the identified nucleoprotein (NP) gene product. This immunodominant NP peptide is recognized by Sendai virus-specific CTL that are known to have therapeutic effects in vivo. By subcutaneous immunization, this peptide induced Sendai virus and NP peptide-specific CTL memory responses in vivo. Most importantly, mice that had been immunized with this peptide were protected against a lethal virus dose, indicating that viral peptides can be used as antiviral T-cell vaccines. The induction of T-cell memory by free peptide immunization potentially has wide applicability in biology and medicine, including protection against infectious disease.
Affiliations:Division of Immunology, The Netherlands Cancer Institute, Amsterdam.
Date:1991
Reference Type:Literature
PubMed ID:1848698
Journal:Proc Natl Acad Sci U S A
Journal Volume:88
Article Pages:2283-7
Journal ISSN:1091-6490
Article Chemical List:Vaccines, Synthetic;Viral Vaccines
Article MeSH List:Animals; Cells, Cultured; Clone Cells; Cytotoxicity, Immunologic; Mice; Mice, Inbred Strains; Parainfluenza Virus 1, Human(genetics; immunology; pathogenicity); Paramyxoviridae Infections(immunology; prevention & control); T-Lymphocytes, Cytotoxic(drug effects; immunology); Vaccines, Synthetic(administration & dosage; pharmacology); Vaccinia virus(genetics); Viral Vaccines(administration & dosage; pharmacology)
Curation Last Updated:2014-07-16 20:56:59