Epitopes described in "Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection."

Reference
Article Authors:Jodie S Haring; Xuefang Jing; Julie Bollenbacher-Reilley; Hai-Hui Xue; Warren J Leonard; John T Harty
Article Title:Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.
Reference Detail
Reference ID:1021311
Abstract:Expression of IL-7Ralpha (CD127) has been suggested as a major determinant in the survival of memory T cell precursors. We investigated whether constitutive expression of IL-7Ralpha on T cells increased expansion and/or decreased contraction of endogenous Ag-specific CD4 and CD8 T cells following infection with Listeria monocytogenes. The results indicate that constitutive expression of IL-7Ralpha alone was not enough to impart an expansion or survival advantage to CD8 T cells responding to infection, and did not increase memory CD8 T cell numbers over those observed in wild-type controls. Constitutive expression of IL-7Ralpha did allow for slightly prolonged expansion of Ag-specific CD4 T cells; however, it did not alter the contraction phase or protect against the waning of memory T cell numbers at later times after infection. Memory CD4 and CD8 T cells generated in IL-7Ralpha transgenic mice expanded similarly to wild-type T cells after secondary infection, and immunized IL-7Ralpha transgenic mice were fully protected against lethal bacterial challenge demonstrating that constitutive expression of IL-7Ralpha does not impair, or markedly improve memory/secondary effector T cell function. These results indicate that expression of IL-7Ralpha alone does not support increased survival of effector Ag-specific CD4 or CD8 T cells into the memory phase following bacterial infection.
Affiliations:Department of Microbiology, Carver School of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Date:2008
Reference Type:Literature
PubMed ID:18292507
Journal:J Immunol
Journal Volume:180
Article Pages:2855-62
Journal ISSN:0022-1767
Article Chemical List:Epitopes, T-Lymphocyte;Growth Inhibitors;Receptors, Interleukin-7;interleukin-7 receptor, alpha chain
Article MeSH List:Animals; CD4-Positive T-Lymphocytes(cytology; immunology; metabolism); CD8-Positive T-Lymphocytes(cytology; immunology; metabolism); Cell Death(genetics; immunology); Cell Proliferation; Cell Survival(genetics; immunology); Epitopes, T-Lymphocyte(genetics; immunology); Growth Inhibitors(biosynthesis; genetics; physiology); Immunologic Memory(genetics); Listeria monocytogenes(immunology); Listeriosis(genetics; immunology; pathology); Lymphocyte Activation(genetics); Lymphocyte Count; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Interleukin-7(biosynthesis; genetics; physiology)
Curation Last Updated:2013-04-25 20:10:21