Epitopes described in "Recombinant Sendai virus induces T cell immunity against respiratory syncytial virus that is protective in the absence of antibodies."

Article Authors:Brigitte Voges; Simone Vallbracht; Gert Zimmer; Sascha Bossow; Wolfgang J Neubert; Kirsten Richter; Elias Hobeika; Georg Herrler; Stephan Ehl
Article Title:Recombinant Sendai virus induces T cell immunity against respiratory syncytial virus that is protective in the absence of antibodies.
Reference Detail
Reference ID:1007841
Abstract:Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and a vaccine is highly desirable. The fusion (F) protein of RSV is an important vaccine target, but the contribution of F-specific T cells to successful vaccination remains unclear. We studied the immune response to vaccination of mice with a recombinant Sendai virus expressing RSV F (rSeV F). rSeV F induced protective neutralizing antibody and RSV F-specific CTL responses. T cell immunity was stronger than that induced by recombinant vaccinia virus (rVV F), a well characterized reference vector. Vaccination of antibody-deficient mice showed that vaccine-induced RSV F-specific T cells were sufficient for protective immunity. rSeV F induced T cell immunity in the presence of neutralizing antibodies, which did not impair the vaccine response. Although the F protein only contains a subdominant CTL epitope, vaccination with rSeV F is sufficient to induce protective T cell immunity against RSV in mice.
Affiliations:Institut für Virologie, Stiftung Tierärztliche Hochschule Hannover, Bünteweg 17, 30559 Hannover, Germany.
Reference Type:Literature
PubMed ID:17904538
Journal:Cell Immunol
Journal Volume:247
Article Pages:85-94
Journal ISSN:1090-2163
Article Chemical List:Antibodies;Viral Fusion Proteins
Article MeSH List:Animals; Antibodies(immunology ); Genetic Engineering; Mice; Mice, Inbred BALB C; Respiratory Syncytial Virus Infections(immunology; pathology; prevention & control ); Respiratory Syncytial Viruses(immunology ); Sendai virus(genetics; immunology ); Solubility; T-Lymphocytes(drug effects; immunology ); Viral Fusion Proteins(genetics; immunology )
Curation Last Updated:2015-07-30 20:21:33