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| Article Authors: | Brigitte Voges; Simone Vallbracht; Gert Zimmer; Sascha Bossow; Wolfgang J Neubert; Kirsten Richter; Elias Hobeika; Georg Herrler; Stephan Ehl |
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| Article Title: | Recombinant Sendai virus induces T cell immunity against respiratory syncytial virus that is protective in the absence of antibodies. |
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| Reference ID: | 1007841 |
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| Abstract: | Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and a vaccine is highly desirable. The fusion (F) protein of RSV is an important vaccine target, but the contribution of F-specific T cells to successful vaccination remains unclear. We studied the immune response to vaccination of mice with a recombinant Sendai virus expressing RSV F (rSeV F). rSeV F induced protective neutralizing antibody and RSV F-specific CTL responses. T cell immunity was stronger than that induced by recombinant vaccinia virus (rVV F), a well characterized reference vector. Vaccination of antibody-deficient mice showed that vaccine-induced RSV F-specific T cells were sufficient for protective immunity. rSeV F induced T cell immunity in the presence of neutralizing antibodies, which did not impair the vaccine response. Although the F protein only contains a subdominant CTL epitope, vaccination with rSeV F is sufficient to induce protective T cell immunity against RSV in mice. |
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| Affiliations: | Institut für Virologie, Stiftung Tierärztliche Hochschule Hannover, Bünteweg 17, 30559 Hannover, Germany. |
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| Date: | 2007 |
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| Reference Type: | Literature |
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| PubMed ID: | 17904538 |
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| Journal: | Cell Immunol |
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| Journal Volume: | 247 |
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| Article Pages: | 85-94 |
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| Journal ISSN: | 1090-2163 |
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| Article Chemical List: | Antibodies;Viral Fusion Proteins |
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| Article MeSH List: | Animals; Antibodies(immunology ); Genetic Engineering; Mice; Mice, Inbred BALB C; Respiratory Syncytial Virus Infections(immunology; pathology; prevention & control ); Respiratory Syncytial Viruses(immunology ); Sendai virus(genetics; immunology ); Solubility; T-Lymphocytes(drug effects; immunology ); Viral Fusion Proteins(genetics; immunology ) |
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| Curation Last Updated: | 2013-05-28 21:14:10 |
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