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| Article Authors: | Shigeru Yutani; Akira Yamada; Kazumi Yoshida; Yukari Takao; Mayumi Tamura; Nobukazu Komatsu; Tatsuya Ide; Masatoshi Tanaka; Michio Sata; Kyogo Itoh |
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| Article Title: | Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy. |
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| Reference ID: | 1005937 |
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| Abstract: | To assess the safety and immune responses to a personalized peptide vaccination of hepatitis C virus (HCV) 1b-derived peptides, 12 HCV1b-positive patients, who were unresponsive to interferon-based therapy, were enrolled in this study. The reactivity of the pre-vaccination peripheral blood T cells and plasma IgG to four vaccine candidate peptides capable of inducing cytotoxic T lymphocytes (CTLs) in HLA-A24(+) patients was examined and only the reactive peptides were then administered bi-weekly at three different dose settings. The study was well tolerated with no severe toxicity. Augmentation of peptide-specific CTL activity and IgG in response to at least one of the vaccinated peptides was observed after the 7th vaccination. Decrease of serum alanine aminotransferase and HCV-RNA levels after the 14th vaccination was also observed in five and three patients, respectively. |
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| Affiliations: | Department of Immunology, Kurume University School of Medicine, Japan. |
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| Date: | 2007 |
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| Reference Type: | Literature |
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| PubMed ID: | 17845828 |
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| Journal: | Vaccine |
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| Journal Volume: | 25 |
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| Article Pages: | 7429-35 |
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| Journal ISSN: | 0264-410X |
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| Article Chemical List: | Hepatitis C Antibodies;Hepatitis C Antigens;Immunoglobulin G;Vaccines, Subunit;Viral Hepatitis Vaccines;Interferons |
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| Article MeSH List: | Adult; Aged; Female; Hepacivirus(immunology); Hepatitis C Antibodies(blood); Hepatitis C Antigens; Hepatitis C, Chronic(immunology; therapy); Humans; Immunity, Cellular; Immunoglobulin G(blood); Interferons(therapeutic use); Male; Middle Aged; Vaccines, Subunit(immunology; therapeutic use); Viral Hepatitis Vaccines(immunology; therapeutic use) |
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| Curation Last Updated: | 2013-05-28 20:55:57 |
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