Epitopes described in "Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy."

Reference
Article Authors:Shigeru Yutani; Akira Yamada; Kazumi Yoshida; Yukari Takao; Mayumi Tamura; Nobukazu Komatsu; Tatsuya Ide; Masatoshi Tanaka; Michio Sata; Kyogo Itoh
Article Title:Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy.
Reference Detail
Reference ID:1005937
Abstract:To assess the safety and immune responses to a personalized peptide vaccination of hepatitis C virus (HCV) 1b-derived peptides, 12 HCV1b-positive patients, who were unresponsive to interferon-based therapy, were enrolled in this study. The reactivity of the pre-vaccination peripheral blood T cells and plasma IgG to four vaccine candidate peptides capable of inducing cytotoxic T lymphocytes (CTLs) in HLA-A24(+) patients was examined and only the reactive peptides were then administered bi-weekly at three different dose settings. The study was well tolerated with no severe toxicity. Augmentation of peptide-specific CTL activity and IgG in response to at least one of the vaccinated peptides was observed after the 7th vaccination. Decrease of serum alanine aminotransferase and HCV-RNA levels after the 14th vaccination was also observed in five and three patients, respectively.
Affiliations:Department of Immunology, Kurume University School of Medicine, Japan.
Date:2007
Reference Type:Literature
PubMed ID:17845828
Journal:Vaccine
Journal Volume:25
Article Pages:7429-35
Journal ISSN:0264-410X
Article Chemical List:Hepatitis C Antibodies;Hepatitis C Antigens;Immunoglobulin G;Vaccines, Subunit;Viral Hepatitis Vaccines;Interferons
Article MeSH List:Adult; Aged; Female; Hepacivirus(immunology); Hepatitis C Antibodies(blood); Hepatitis C Antigens; Hepatitis C, Chronic(immunology; therapy); Humans; Immunity, Cellular; Immunoglobulin G(blood); Interferons(therapeutic use); Male; Middle Aged; Vaccines, Subunit(immunology; therapeutic use); Viral Hepatitis Vaccines(immunology; therapeutic use)
Curation Last Updated:2013-05-28 20:55:57