Epitopes described in "Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation."

Article Authors:Thomas Korn; Jayagopala Reddy; Wenda Gao; Estelle Bettelli; Amit Awasthi; Troels R Petersen; B Thomas Bäckström; Raymond A Sobel; Kai W Wucherpfennig; Terry B Strom; Mohamed Oukka; Vijay K Kuchroo
Article Title:Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
Reference Detail
Reference ID:1015484
Abstract:Treatment with ex vivo-generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases. However, the dynamics and function of T-reg in autoimmunity are not well understood. Thus, we developed Foxp3gfp knock-in (Foxp3gfp.KI) mice and myelin oligodendrocyte glycoprotein (MOG)(35-55)/IA(b) (MHC class II) tetramers to track autoantigen-specific effector T cells (T-eff) and T-reg in vivo during experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. MOG tetramer-reactive, Foxp3(+) T-reg expanded in the peripheral lymphoid compartment and readily accumulated in the central nervous system (CNS), but did not prevent the onset of disease. Foxp3(+) T cells isolated from the CNS were effective in suppressing naive MOG-specific T cells, but failed to control CNS-derived encephalitogenic T-eff that secreted interleukin (IL)-6 and tumor necrosis factor (TNF). Our data suggest that in order for CD4(+)Foxp3(+) T-reg to effectively control autoimmune reactions in the target organ, it may also be necessary to control tissue inflammation.
Affiliations:Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Reference Type:Literature
PubMed ID:17384649
Journal:Nat Med
Journal Volume:13
Article Pages:423-31
Journal ISSN:1078-8956
Article Chemical List:Forkhead Transcription Factors;Foxp3 protein, mouse;Glycoproteins;Myelin-Oligodendrocyte Glycoprotein;Peptide Fragments;myelin oligodendrocyte glycoprotein (35-55);Green Fluorescent Proteins
Article MeSH List:Animals; Autoimmunity(immunology); Brain(immunology); Encephalomyelitis, Autoimmune, Experimental(immunology); Forkhead Transcription Factors(metabolism); Glycoproteins(immunology; metabolism); Green Fluorescent Proteins(metabolism); Immunohistochemistry; Immunotherapy(methods); Mice; Models, Immunological; Multiple Sclerosis(immunology); Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments(immunology; metabolism); T-Lymphocytes, Regulatory(immunology)
Curation Last Updated:2015-07-30 20:31:05