Epitopes described in "Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II."

Article Authors:Dirk Homann; Hanna Lewicki; David Brooks; Jens Eberlein; Valerie Mallet-Designé; Luc Teyton; Michael B A Oldstone
Article Title:Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II.
Reference Detail
Reference ID:1007685
Abstract:Virus-specific CD4(+) T cells contribute to effective virus control through a multiplicity of mechanisms including direct effector functions as well as "help" for B cell and CD8(+) T cell responses. Here, we have used the lymphocytic choriomeningitis virus (LCMV) system to assess the minimal constraints of a dominant antiviral CD4(+) T cell response. We report that the core epitope derived from the LCMV glycoprotein (GP) is 11 amino acids in length and provides optimal recognition by epitope-specific CD4(+) T cells. Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction.
Affiliations:Barbara Davis Center, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora CO, USA.
Reference Type:Literature
PubMed ID:17320138
Journal Volume:363
Article Pages:113-23
Journal ISSN:0042-6822
Article Chemical List:Epitopes, T-Lymphocyte;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;Immunodominant Epitopes;Receptors, Antigen, T-Cell
Article MeSH List:Amino Acid Sequence; Animals; CD4-Positive T-Lymphocytes(immunology); Epitope Mapping; Epitopes, T-Lymphocyte(chemistry; immunology); Histocompatibility Antigens Class I(immunology); Histocompatibility Antigens Class II(immunology); Immunodominant Epitopes(immunology); Lymphocytic choriomeningitis virus(immunology); Mice; Molecular Sequence Data; Receptors, Antigen, T-Cell(genetics; immunology; metabolism); T-Lymphocytes, Cytotoxic(immunology)
Curation Last Updated:2015-07-30 20:21:25