Epitopes described in "Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection."

Reference
Article Authors:John A Rutigliano; Tracy J Ruckwardt; Julie E Martin; Barney S Graham
Article Title:Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.
Reference Detail
Reference ID:1006056
Abstract:CD8+ cytotoxic T lymphocytes are key effectors of adaptive immunity for the control of virus infections. Epitope-specific responses are hierarchical and the rules for dominance are not well defined. Here we show that the H2-Kd-restricted RSV M2(82-90) (KdM2(82-90)) epitope dominates the H2-Db-restricted RSV M187-195 (DbM187-195) epitope and influences epitope-specific effector function in the acute and memory phases of the immune response to primary RSV infection in H-2b/d hybrid mice. The hybrid mouse model provides a system to define rules of epitope hierarchy and better understand how antigen presentation and epitope competition affect the phenotype of effector and memory T cells.
Date:2007
Reference Type:Literature
PubMed ID:17275872
Journal:Virology
Journal Volume:362
Article Pages:314-9
Journal ISSN:0042-6822
Article Chemical List:Cytokines;Epitopes, T-Lymphocyte;Immunodominant Epitopes
Article MeSH List:Animals; CD8-Positive T-Lymphocytes(immunology); Cell Line; Crosses, Genetic; Cytokines(immunology); Disease Models, Animal; Epitopes, T-Lymphocyte(immunology); Female; Humans; Hybridization, Genetic(immunology); Immunodominant Epitopes(immunology); Immunologic Memory; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Respiratory Syncytial Virus Infections(immunology); Respiratory Syncytial Viruses(immunology); Specific Pathogen-Free Organisms
Curation Last Updated:2014-10-03 20:44:55