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| Article Authors: | John A Rutigliano; Tracy J Ruckwardt; Julie E Martin; Barney S Graham |
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| Article Title: | Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection. |
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| Reference ID: | 1006056 |
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| Abstract: | CD8+ cytotoxic T lymphocytes are key effectors of adaptive immunity for the control of virus infections. Epitope-specific responses are hierarchical and the rules for dominance are not well defined. Here we show that the H2-Kd-restricted RSV M2(82-90) (KdM2(82-90)) epitope dominates the H2-Db-restricted RSV M187-195 (DbM187-195) epitope and influences epitope-specific effector function in the acute and memory phases of the immune response to primary RSV infection in H-2b/d hybrid mice. The hybrid mouse model provides a system to define rules of epitope hierarchy and better understand how antigen presentation and epitope competition affect the phenotype of effector and memory T cells. |
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| Affiliations: | Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 2502, 40 Convent Drive, MSC 3017, Bethesda, MD 20892-3017, USA. |
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| Date: | 2007 |
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| Reference Type: | Literature |
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| PubMed ID: | 17275872 |
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| Journal: | Virology |
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| Journal Volume: | 362 |
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| Article Pages: | 314-9 |
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| Journal ISSN: | 0042-6822 |
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| Article Chemical List: | Cytokines;Epitopes, T-Lymphocyte;Immunodominant Epitopes |
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| Article MeSH List: | Animals; CD8-Positive T-Lymphocytes(immunology); Cell Line; Crosses, Genetic; Cytokines(immunology); Disease Models, Animal; Epitopes, T-Lymphocyte(immunology); Female; Humans; Hybridization, Genetic(immunology); Immunodominant Epitopes(immunology); Immunologic Memory; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Respiratory Syncytial Virus Infections(immunology); Respiratory Syncytial Viruses(immunology); Specific Pathogen-Free Organisms |
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| Curation Last Updated: | 2011-10-25 00:20:28 |
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