Epitopes described in "Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C."

Article Authors:David E Kaplan; Kazushi Sugimoto; Kimberly Newton; Mary E Valiga; Fusao Ikeda; Ayse Aytaman; Frederick A Nunes; Michael R Lucey; Barbara A Vance; Robert H Vonderheide; K Rajender Reddy; Jane A McKeating; Kyong-Mi Chang
Article Title:Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.
Reference Detail
Reference ID:1003659
Abstract:BACKGROUND & AIMS: Acute hepatitis C virus (HCV) infection becomes chronic in the majority of patients. Although HCV-specific CD4 T-cell response is associated with HCV clearance, less is known about virus-specific CD8 T-cell or neutralizing antibody (nAb) responses and the role of CD4 help in their induction during acute infection. METHODS: HCV-specific CD4, CD8, and HCV pseudoparticle (HCVpp) nAb responses were monitored in acutely HCV-infected patients to define their relative contributions to viral clearance. RESULTS: Our results show that the outcome of acute hepatitis C is associated with a functional hierarchy in HCV-specific CD4 T-cell response and the scope of virus-specific, total T-cell interferon-gamma response. HCV-specific CD8 T-cell response was readily detectable in acutely HCV-infected patients regardless of virologic outcome or virus-specific CD4 T-cell response. In contrast, HCVpp-specific nAbs were readily detected in patients with chronic evolution and impaired virus-specific CD4 T-cell response but not in patients who cleared infection with robust virus-specific CD4 T-cell response. CONCLUSIONS: The outcome of acute hepatitis C is associated with efficient virus-specific CD4 T-cell response(s) without which HCV-specific CD8 T-cell and heterologous nAb responses may develop but fail to clear viremia. Furthermore, HCV-specific nAb responses may not be induced despite robust virus-specific CD4 T-cell response.
Reference Type:Literature
PubMed ID:17258733
Journal Volume:132
Article Pages:654-66
Journal ISSN:0016-5085
Article Chemical List:Hepatitis C Antibodies;RNA, Viral;Interferon-gamma
Article MeSH List:Acute Disease; Adult; Aged; CD4-Positive T-Lymphocytes(immunology; metabolism; virology); CD8-Positive T-Lymphocytes(immunology; metabolism; virology); Female; Follow-Up Studies; Hepacivirus(genetics; immunology); Hepatitis C(immunology; metabolism; virology); Hepatitis C Antibodies(blood); Hepatitis C, Chronic(immunology; virology); Humans; Interferon-gamma(biosynthesis); Lymphocyte Activation; Male; Middle Aged; Prognosis; RNA, Viral(blood); Time Factors; United States; Virion(immunology)
Curation Last Updated:2015-07-24 20:07:21