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| Article Authors: | Herbert P M Brok; Leonie Boven; Marjan van Meurs; Nicole Kerlero de Rosbo; Liesbeth Celebi-Paul; Yolanda S Kap; Anwar Jagessar; Rogier Q Hintzen; Geoff Keir; Jeffrey Bajramovic; Avraham Ben-Nun; Jan Bauer; Jon D Laman; Sandra Amor; Bert A 't Hart |
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| Article Title: | The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys. |
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| Reference ID: | 1015521 |
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| Abstract: | Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG(34-56). Monkeys sensitized against the viral peptide and subsequently challenged with MOG(34-56) display histological signs of encephalitis, but do not show overt neurological signs. |
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| Affiliations: | Department of Immunobiology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands. |
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| Date: | 2007 |
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| Reference Type: | Literature |
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| PubMed ID: | 17126916 |
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| Journal: | J Neuroimmunol |
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| Journal Volume: | 182 |
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| Article Pages: | 135-52 |
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| Journal ISSN: | 0165-5728 |
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| Article Chemical List: | Antibodies;Capsid Proteins;Epitopes, T-Lymphocyte;Glycoproteins;Myelin-Associated Glycoprotein;Peptide Fragments;Polyethylene Glycols;Recombinant Proteins;major capsid protein, Cytomegalovirus;myelin oligodendrocyte glycoprotein (34-56);oligodendrocyte-myelin glycoprotein;polyoxyethanyl 600 cholesteryl sebacate;Cholesterol |
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| Article MeSH List: | Animals; Antibodies(blood); Brain(pathology); CD4-Positive T-Lymphocytes(immunology); CD8-Positive T-Lymphocytes(immunology); Capsid Proteins(immunology; pharmacology); Cell Line; Cell Proliferation(drug effects); Cholesterol(analogs & derivatives; immunology); Cross Reactions; Encephalomyelitis, Autoimmune, Experimental(immunology; pathology; physiopathology); Epitopes, T-Lymphocyte(immunology); Female; Glycoproteins(immunology); Humans; Lymphocyte Activation; Macaca mulatta(immunology); Male; Monocytes(pathology); Myelin-Associated Glycoprotein(immunology; pharmacology); Peptide Fragments(immunology; pharmacology); Polyethylene Glycols; Recombinant Proteins(immunology); Spinal Cord(pathology) |
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| Curation Last Updated: | 2011-02-23 23:39:43 |
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