Epitopes described in "The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys."

Reference
Article Authors:Herbert P M Brok; Leonie Boven; Marjan van Meurs; Nicole Kerlero de Rosbo; Liesbeth Celebi-Paul; Yolanda S Kap; Anwar Jagessar; Rogier Q Hintzen; Geoff Keir; Jeffrey Bajramovic; Avraham Ben-Nun; Jan Bauer; Jon D Laman; Sandra Amor; Bert A 't Hart
Article Title:The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.
Reference Detail
Reference ID:1015521
Abstract:Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG(34-56). Monkeys sensitized against the viral peptide and subsequently challenged with MOG(34-56) display histological signs of encephalitis, but do not show overt neurological signs.
Date:2007
Reference Type:Literature
PubMed ID:17126916
Journal:J Neuroimmunol
Journal Volume:182
Article Pages:135-52
Journal ISSN:0165-5728
Article Chemical List:Antibodies;Capsid Proteins;Epitopes, T-Lymphocyte;Glycoproteins;MOG protein, human;Myelin Proteins;Myelin-Associated Glycoprotein;Myelin-Oligodendrocyte Glycoprotein;Peptide Fragments;Polyethylene Glycols;Recombinant Proteins;major capsid protein, Cytomegalovirus;myelin oligodendrocyte glycoprotein (34-56);polyoxyethanyl 600 cholesteryl sebacate;Cholesterol
Article MeSH List:Animals; Antibodies(blood); Brain(pathology); CD4-Positive T-Lymphocytes(immunology); CD8-Positive T-Lymphocytes(immunology); Capsid Proteins(immunology; pharmacology); Cell Line; Cell Proliferation(drug effects); Cholesterol(analogs & derivatives; immunology); Cross Reactions; Encephalomyelitis, Autoimmune, Experimental(immunology; pathology; physiopathology); Epitopes, T-Lymphocyte(immunology); Female; Glycoproteins(immunology); Humans; Lymphocyte Activation; Macaca mulatta(immunology); Male; Monocytes(pathology); Myelin Proteins; Myelin-Associated Glycoprotein(immunology; pharmacology); Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments(immunology; pharmacology); Polyethylene Glycols; Recombinant Proteins(immunology); Spinal Cord(pathology)
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