Epitopes described in "Paternal antigen-bearing cells transferred during insemination do not stimulate anti-paternal CD8+ T cells: role of estradiol in locally inhibiting CD8+ T cell responses."

Reference
Article Authors:Matthew M Seavey; Tim R Mosmann
Article Title:Paternal antigen-bearing cells transferred during insemination do not stimulate anti-paternal CD8+ T cells: role of estradiol in locally inhibiting CD8+ T cell responses.
Reference Detail
Reference ID:1020129
Abstract:Maternal immunological tolerance of the semiallogeneic fetus involves several overlapping mechanisms to balance maternal immunity and fetal development. Anti-paternal CD8+ T cells are suppressed during pregnancy in some but not all mouse models. Since semen has been shown to mediate immune modulation, we tested whether exposure to paternal Ag during insemination activated or tolerized anti-paternal CD8+ T cells. The uterine lumen of mated female mice contained male MHC I+ cells that stimulated effector, but not naive, CD8+ T cells ex vivo. Maternal MHC class I+ myeloid cells fluxed into the uterine lumen in response to mating and cross-presented male H-Y Ag to effector, but not naive, CD8+ T cells ex vivo. However, neither unprimed nor previously primed TCR-transgenic CD8+ T cells specific for either paternal MHC I or H-Y Ag proliferated in vivo after mating. These T cells subsequently responded normally to i.p. challenge, implicating ignorance rather than anergy as the main reason for the lack of response. CD8+ T cells responded to either peptide Ag or male cells delivered intravaginally in ovariectomized mice, but this response was inhibited by systemic estradiol (inducing an estrus-like state). Subcutaneous Ag induced responses in both cases. Allogeneic dendritic cells did not induce responses intravaginally even in ovariectomized mice in the absence of estradiol. These results suggest that inhibition of antiallogeneic responses is restricted both locally to the reproductive tract and temporally to the estrous phase of the menstrual cycle, potentially decreasing the risk of maternal immunization against paternal Ags during insemination.
Date:2006
Reference Type:Literature
PubMed ID:17114426
Journal:J Immunol
Journal Volume:177
Article Pages:7567-78
Journal ISSN:0022-1767
Article Chemical List:Histocompatibility Antigens Class I;Receptors, Antigen, T-Cell;Estradiol
Article MeSH List:Animals; Antigen Presentation(immunology); Antigen-Presenting Cells(immunology); CD8-Positive T-Lymphocytes(immunology); Estradiol(immunology); Female; Flow Cytometry; Histocompatibility Antigens Class I(immunology); Immune Tolerance; Insemination; Lymphocyte Activation(immunology); Male; Mice; Mice, Transgenic; Ovariectomy; Pregnancy; Receptors, Antigen, T-Cell(genetics; immunology); Uterus(immunology)
Curation Last Updated:2014-05-15 21:10:20