Epitopes described in "Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C."

Article Authors:Tobias Manigold; Eui-Cheol Shin; Eishiro Mizukoshi; Kathleen Mihalik; Krishna K Murthy; Charles M Rice; Ciriaco A Piccirillo; Barbara Rehermann
Article Title:Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.
Reference Detail
Reference ID:1025952
Abstract:Hepatitis C virus (HCV) poses a global health problem because it readily establishes persistent infection and a vaccine is not available. CD4(+)CD25(+) T cells have been implicated in HCV persistence because their frequency is increased in the blood of HCV-infected patients and their in vitro depletion results in increased IFN-gamma production by HCV-specific T cells. Studying a well-characterized cohort of 16 chimpanzees, the sole animal model for HCV infection, we here demonstrate that the frequency of Foxp3(+)CD4(+)CD25(+) regulatory T cells (T(Regs)) and the extent of suppression was as high in spontaneously HCV-recovered chimpanzees as in persistently HCV-infected chimpanzees. Foxp3(+)CD4(+)CD25(+) T(Regs) suppressed IFN-gamma production, expansion, and activation-induced cell death of HCV-specific T cells after recovery from HCV infection and in persistent HCV infection. Thus, T(Reg) cells control HCV-specific T cells not only in persistent infection but also after recovery, where they may regulate memory T-cell responses by controlling their activation and preventing apoptosis. However, Foxp3(+)CD4(+)CD25(+) T(Reg) cells of both HCV-recovered and HCV-infected chimpanzees differed from Foxp3(+)CD4(+)CD25(+)T(Reg) cells of HCV-naive chimpanzees in increased IL-2 responsiveness and lower T-cell receptor excision circle content, implying a history of in vivo proliferation. This result suggests that HCV infection alters the population of Foxp3(+)CD4(+)CD25(+) T(Reg) cells.
Affiliations:Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Reference Type:Literature
PubMed ID:16478885
Journal Volume:107
Article Pages:4424-32
Journal ISSN:0006-4971
Article Chemical List:Forkhead Transcription Factors;Interferon-gamma
Article MeSH List:Animals; Apoptosis; Forkhead Transcription Factors(immunology; physiology); Hepacivirus(immunology); Hepatitis C(immunology); Immunologic Memory; Interferon-gamma; Lymphocyte Activation; Pan troglodytes; T-Cell Antigen Receptor Specificity; T-Lymphocytes(immunology); T-Lymphocytes, Regulatory(immunology; physiology)
Curation Last Updated:2015-07-24 20:11:21