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| Article Authors: | Shalyn C Clute; Levi B Watkin; Markus Cornberg; Yuri N Naumov; John L Sullivan; Katherine Luzuriaga; Raymond M Welsh; Liisa K Selin |
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| Article Title: | Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. |
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| Reference ID: | 1000190 |
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| Abstract: | The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the diversity and size of the memory CD8+ T cell population increase with age, we questioned whether IM was mediated by the reactivation of memory CD8+ T cells specific to previously encountered pathogens but cross-reactive with EBV. Of 8 HLA-A2+ IM patients, 5 had activated T cells specific to another common virus, as evidenced by a significantly higher number of peripheral blood influenza A virus M1(58-66)-specific T cells compared with healthy immune donors. Two patients with an augmented M1 response had tetramer-defined cross-reactive cells recognizing influenza M1 and EBV-BMLF1(280-288), which accounted for up to one-third of their BMLF1-specific population and likely contributed to a skewed M1-specific T cell receptor repertoire. These epitopes, with only 33% sequence similarity, mediated differential effects on the function of the cross-reactive T cells, which may contribute to alterations in disease outcome. EBV could potentially encode an extensive pool of T cell epitopes that activate other cross-reactive memory T cells. Our results support the concept that cross-reactive memory CD8+ T cells activated by EBV contribute to the characteristic lymphoproliferation of IM. |
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| Affiliations: | Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. |
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| Date: | 2005 |
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| Reference Type: | Literature |
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| PubMed ID: | 16308574 |
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| Journal: | J Clin Invest |
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| Journal Volume: | 115 |
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| Article Pages: | 3602-12 |
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| Journal ISSN: | 0021-9738 |
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| Article Chemical List: | Chemokine CCL4;Epitopes;HLA-A2 Antigen;Macrophage Inflammatory Proteins;Peptides;Receptors, Antigen, T-Cell;Interferon-gamma |
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| Article MeSH List: | Adolescent; Adult; CD8-Positive T-Lymphocytes(cytology; immunology; metabolism; virology); Cell Proliferation; Chemokine CCL4; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epitopes(chemistry); Flow Cytometry; Genes, MHC Class I; HLA-A2 Antigen(chemistry); Herpesvirus 4, Human(metabolism); Humans; Immunologic Memory; Infectious Mononucleosis(virology); Influenza A virus(immunology); Interferon-gamma(metabolism); K562 Cells; Leukocytes, Mononuclear(cytology); Lymphocyte Activation; Lymphocytes(cytology; virology); Macrophage Inflammatory Proteins(metabolism); Orthomyxoviridae(genetics); Peptides(chemistry); Receptors, Antigen, T-Cell(metabolism); T-Lymphocytes(immunology; virology); Time Factors |
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| Curation Last Updated: | 2011-10-24 20:39:10 |
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