Epitopes described in "Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination."

Article Authors:Vladimir P Badovinac; Kelly A N Messingham; Ali Jabbari; Jodie S Haring; John T Harty
Article Title:Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.
Reference Detail
Reference ID:1021319
Abstract:Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4-6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-gamma receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-gamma on the responding T cells, control the rate of development of memory CD8+ T cells.
Affiliations:Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa, Iowa City, Iowa 52240, USA.
Reference Type:Literature
PubMed ID:15951824
Journal:Nat Med
Journal Volume:11
Article Pages:748-56
Journal ISSN:1078-8956
Article Chemical List:Receptors, Interferon;interferon gamma receptor;Interferon-gamma
Article MeSH List:Animals; CD8-Positive T-Lymphocytes(immunology); CpG Islands; Dendritic Cells(immunology); Immunization, Secondary; Immunologic Memory; Inflammation(immunology; metabolism); Interferon-gamma(metabolism); Listeria monocytogenes(immunology; pathogenicity); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Receptors, Interferon(genetics; metabolism); Vaccination(methods)
Curation Last Updated:2015-07-30 20:38:44