Epitopes described in "The molecular basis for oat intolerance in patients with celiac disease."

Reference
Article Authors:Helene Arentz-Hansen; Burkhard Fleckenstein; Øyvind Molberg; Helge Scott; Frits Koning; Günther Jung; Peter Roepstorff; Knut E A Lundin; Ludvig M Sollid
Article Title:The molecular basis for oat intolerance in patients with celiac disease.
Reference Detail
Reference ID:1013408
Abstract:BACKGROUND: Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations. It is caused by an inappropriate immune response to dietary gluten and is treated with a gluten-free diet. Recent feeding studies have indicated oats to be safe for celiac disease patients, and oats are now often included in the celiac disease diet. This study aimed to investigate whether oat intolerance exists in celiac disease and to characterize the cells and processes underlying this intolerance. METHODS AND FINDINGS: We selected for study nine adults with celiac disease who had a history of oats exposure. Four of the patients had clinical symptoms on an oats-containing diet, and three of these four patients had intestinal inflammation typical of celiac disease at the time of oats exposure. We established oats-avenin-specific and -reactive intestinal T-cell lines from these three patients, as well as from two other patients who appeared to tolerate oats. The avenin-reactive T-cell lines recognized avenin peptides in the context of HLA-DQ2. These peptides have sequences rich in proline and glutamine residues closely resembling wheat gluten epitopes. Deamidation (glutamine-->glutamic acid conversion) by tissue transglutaminase was involved in the avenin epitope formation. CONCLUSIONS: We conclude that some celiac disease patients have avenin-reactive mucosal T-cells that can cause mucosal inflammation. Oat intolerance may be a reason for villous atrophy and inflammation in patients with celiac disease who are eating oats but otherwise are adhering to a strict gluten-free diet. Clinical follow-up of celiac disease patients eating oats is advisable.
Date:2004
Reference Type:Literature
PubMed ID:15526039
Journal:PLoS Med
Journal Volume:1
Article Pages:e1
Journal ISSN:1549-1676
Article Chemical List:Plant Proteins;Prolamins
Article MeSH List:Atrophy; Avena sativa; Celiac Disease(physiopathology); Diet; Humans; Inflammation; Intestinal Mucosa(immunology; pathology); Plant Proteins(immunology); Prolamins; T-Lymphocytes(immunology)
Curation Last Updated:2014-05-14 21:13:06