Epitopes described in "A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes."

Article Authors:Urs Christen; Kurt H Edelmann; Dorian B McGavern; Tom Wolfe; Bryan Coon; Meghann K Teague; Stephen D Miller; Michael B A Oldstone; Matthias G von Herrath
Article Title:A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.
Reference Detail
Reference ID:1000536
Abstract:We document here that infection of prediabetic mice with a virus expressing an H-2Kb-restricted mimic ligand to a self epitope present on beta cells accelerates the development of autoimmune diabetes. Immunization with the mimic ligand expanded autoreactive T cell populations, which was followed by their trafficking to the islets, as visualized in situ by tetramer staining. In contrast, the mimic ligand did not generate sufficient autoreactive T cells in naive mice to initiate disease. Diabetes acceleration did not occur in H-2Kb-deficient mice or in mice tolerized to the mimic ligand. Thus, arenavirus-expressed mimics of self antigens accelerate a previously established autoimmune process. Sequential heterologous viral infections might therefore act in concert to precipitate clinical autoimmune disease, even if single exposure to a viral mimic does not always cause sufficient tissue destruction.
Affiliations:Immune Regulation Lab, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.
Reference Type:Literature
PubMed ID:15520861
Journal:J Clin Invest
Journal Volume:114
Article Pages:1290-8
Journal ISSN:0021-9738
Article Chemical List:Autoantigens;Blood Glucose;Cytokines;Epitopes;Ligands
Article MeSH List:Animals; Autoantigens(chemistry); B-Lymphocytes(immunology); Blood Glucose(metabolism); CD8-Positive T-Lymphocytes(immunology); Cytokines(biosynthesis); Diabetes Mellitus, Experimental(immunology); Diabetes Mellitus, Type 1(immunology); Disease Models, Animal; Epitopes(chemistry); Immunohistochemistry; Ligands; Mice; Mice, Inbred C57BL; T-Lymphocytes(metabolism); T-Lymphocytes, Cytotoxic(metabolism); Time Factors; Transgenes
Curation Last Updated:2015-07-30 20:05:42