Epitopes described in "Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy."

Reference
Article Authors:George J M Webster; Stephanie Reignat; David Brown; Graham S Ogg; Louise Jones; Suranjith L Seneviratne; Roger Williams; Geoffrey Dusheiko; Antonio Bertoletti
Article Title:Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy.
Reference Detail
Reference ID:1003493
Abstract:The cytotoxic T-cell response in chronic hepatitis B virus (HBV) infection has been described as weak and mono- or oligospecific in comparison to the more robust virus-specific T-cell response present in resolved infection. However, chronic hepatitis B is a heterogeneous disease with markedly variable levels of virus replication and liver disease activity. Here we analyzed (both directly ex vivo and after in vitro stimulation) the HBV-specific CD8 T-cell responses against structural and nonstructural HBV proteins longitudinally in patients with different patterns of chronic infections. We found that the profiles of virus-specific CD8(+)-T-cell responses during chronic infections are highly heterogeneous and influenced more by the level of HBV replication than by the activity of liver disease. An HBV DNA load of <10(7) copies/ml appears to be the threshold below which circulating multispecific HBV-specific CD8(+) T cells are consistently detected. Furthermore, CD8(+) T cells with different specificities are differentially regulated during chronic infections. HBV core-specific CD8(+) T cells are associated with viral control, while CD8(+) T cells specific for envelope and polymerase epitopes can occasionally be found in the setting of high levels (>10(7) copies) of HBV replication. These findings have implications for the design of immunotherapy for chronic HBV infections.
Date:2004
Reference Type:Literature
PubMed ID:15140968
Journal:J Virol
Journal Volume:78
Article Pages:5707-19
Journal ISSN:1098-5514
Article Chemical List:DNA, Viral;Viral Nonstructural Proteins;Viral Structural Proteins
Article MeSH List:Adult; CD8-Positive T-Lymphocytes(immunology); DNA, Viral(analysis); Female; Hepatitis B, Chronic(immunology; therapy); Humans; Immunotherapy; Longitudinal Studies; Male; Middle Aged; Viral Nonstructural Proteins(immunology); Viral Structural Proteins(immunology); Virus Replication
Curation Last Updated:2014-10-03 20:25:35