Epitopes described in "Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection."

Article Authors:Daniele Accapezzato; Vittorio Francavilla; Marino Paroli; Marco Casciaro; Lucia Valeria Chircu; Agostino Cividini; Sergio Abrignani; Mario U Mondelli; Vincenzo Barnaba
Article Title:Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection.
Reference Detail
Reference ID:1001440
Abstract:Regulatory T (T(R)) cells consist of phenotypically and functionally distinct CD4(+) and CD8(+) T cell subsets engaged both in maintaining self-tolerance and in preventing anti-non-self effector responses (microbial, tumor, transplant, and so on) that may be harmful to the host. Here we propose that the proinflammatory function of virus-specific memory effector CCR7(-)CD8(+) T cells, which are massively recruited in the liver, are inefficient (in terms of IFN-gamma production) in patients with chronic hepatitis C virus (HCV) infection because of the concomitant presence of virus-specific CCR7(-)CD8(+) T(R) cells producing considerable amounts of IL-10. These CD8(+) T(R) cells are antigen specific, as they can be stimulated by HCV epitopes and suppress T cell responses that are in turn restored by the addition of neutralizing anti-IL-10. This study provides for the first time to our knowledge direct evidence of the existence of virus-specific CD8(+) T(R) cells that infiltrate the livers of patients with chronic HCV infection, identifies IL-10 as a soluble inhibitory factor mediating suppression, and suggests that these cells play a pivotal role in controlling hepatic effector CD8(+) T cell responses.
Affiliations:Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Università degli Studi di Roma La Sapienza, Rome, Italy.
Reference Type:Literature
PubMed ID:15057302
Journal:J Clin Invest
Journal Volume:113
Article Pages:963-72
Journal ISSN:0021-9738
Article Chemical List:CCR7 protein, human;Receptors, CCR7;Receptors, Chemokine;Interleukin-10
Article MeSH List:Adult; Aged; CD8-Positive T-Lymphocytes(metabolism); Cell Division(physiology); Hepatitis C(metabolism); Humans; Interleukin-10(metabolism); Liver(metabolism); Middle Aged; Receptors, CCR7; Receptors, Chemokine(metabolism); T-Lymphocytes, Cytotoxic(metabolism)
Curation Last Updated:2015-07-24 20:02:15