Epitopes described in "Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease."

Reference
Article Authors:Susana A Laucella; Miriam Postan; Diana Martin; Bolyn Hubby Fralish; Maria C Albareda; Maria G Alvarez; Bruno Lococo; Gustavo Barbieri; Rodolfo J Viotti; Rick L Tarleton
Article Title:Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease.
Reference Detail
Reference ID:1005850
Abstract:This study sought to quantify CD8(+) T cell responses to Trypanosoma cruzi and to identify potential links between these responses and the severity of disease in humans. In the majority of patients with Chagas disease, staining with class I major histocompatibility complex tetramers and analysis of interferon (IFN)- gamma ELISPOT responses to a panel of known cytotoxic T lymphocyte target epitopes from T. cruzi failed to identify parasite-specific CD8(+) T cells. However, the frequency of individuals with positive ELISPOT responses was higher in areas of active transmission. Analysis of IFN- gamma ELISPOT responses to a parasite lysate revealed a very high frequency of responders among patients with mild clinical disease and a very low frequency of responders among those with the most severe form of the disease. These data suggest that the frequency of IFN- gamma -producing T cells in patients with chronic Chagas disease is associated with the history of recent exposure and with the clinical status of the patient.
Affiliations:Instituto Nacional de Parasitologia "Dr. Mario Fatala Chaben," Buenos Aires, Argentina.
Date:2004
Reference Type:Literature
PubMed ID:14976609
Journal:J Infect Dis
Journal Volume:189
Article Pages:909-18
Journal ISSN:1537-6613
Article Chemical List:Biological Markers;HLA-A2 Antigen;Peptide Fragments;Interferon-gamma
Article MeSH List:Animals; Biological Markers(blood); CD8-Positive T-Lymphocytes(immunology); Chagas Disease(immunology; physiopathology); HLA-A2 Antigen(chemistry; immunology); Histocompatibility Testing; Humans; Interferon-gamma(immunology); Peptide Fragments(chemistry; immunology); Reference Values; Severity of Illness Index; T-Lymphocytes(immunology); T-Lymphocytes, Cytotoxic(immunology); Trypanosoma cruzi(immunology)
Curation Last Updated:2014-10-03 20:43:42