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| Article Authors: | Arash Grakoui; Naglaa H Shoukry; David J Woollard; Jin-Hwan Han; Holly L Hanson; John Ghrayeb; Krishna K Murthy; Charles M Rice; Christopher M Walker |
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| Article Title: | HCV persistence and immune evasion in the absence of memory T cell help. |
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| Reference ID: | 1001791 |
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| Abstract: | Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ Tcells are essential for this protection. Antibody-mediated depletion of CD4+ Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8+ Tcell responses. Incomplete control of HCV replication by memory CD8+ Tcells in the absence of adequate CD4+ Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex-restricted epitopes and failure to resolve HCV infection. |
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| Affiliations: | Center for the Study of Hepatitis C, Rockefeller University, New York, NY 10021, USA. |
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| Date: | 2003 |
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| Reference Type: | Literature |
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| PubMed ID: | 14576438 |
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| Journal: | Science |
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| Journal Volume: | 302 |
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| Article Pages: | 659-62 |
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| Journal ISSN: | 1095-9203 |
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| Article Chemical List: | Antigens, Viral;Epitopes;Viral Core Proteins;Viral Nonstructural Proteins;nucleocapsid protein, Hepatitis C virus |
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| Article MeSH List: | Amino Acid Sequence; Amino Acid Substitution; Animals; Antigen Presentation; Antigens, Viral(chemistry; genetics; immunology); CD4-Positive T-Lymphocytes(immunology); CD8-Positive T-Lymphocytes(immunology); Epitopes; Evolution, Molecular; Hepacivirus(genetics; immunology; physiology); Hepatitis C(immunology; virology); Immunologic Memory; Liver(immunology); Major Histocompatibility Complex; Molecular Sequence Data; Mutation; Pan troglodytes; T-Lymphocyte Subsets(immunology); Time Factors; Viral Core Proteins(chemistry; genetics; immunology); Viral Nonstructural Proteins(chemistry; genetics; immunology); Viremia; Virus Replication |
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| Curation Last Updated: | 2011-10-24 21:13:41 |
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