Epitopes described in "HCV persistence and immune evasion in the absence of memory T cell help."

Article Authors:Arash Grakoui; Naglaa H Shoukry; David J Woollard; Jin-Hwan Han; Holly L Hanson; John Ghrayeb; Krishna K Murthy; Charles M Rice; Christopher M Walker
Article Title:HCV persistence and immune evasion in the absence of memory T cell help.
Reference Detail
Reference ID:1001791
Abstract:Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ Tcells are essential for this protection. Antibody-mediated depletion of CD4+ Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8+ Tcell responses. Incomplete control of HCV replication by memory CD8+ Tcells in the absence of adequate CD4+ Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex-restricted epitopes and failure to resolve HCV infection.
Affiliations:Center for the Study of Hepatitis C, Rockefeller University, New York, NY 10021, USA.
Reference Type:Literature
PubMed ID:14576438
Journal Volume:302
Article Pages:659-62
Journal ISSN:1095-9203
Article Chemical List:Antigens, Viral;Epitopes;Viral Core Proteins;Viral Nonstructural Proteins;nucleocapsid protein, Hepatitis C virus
Article MeSH List:Amino Acid Sequence; Amino Acid Substitution; Animals; Antigen Presentation; Antigens, Viral(chemistry; genetics; immunology); CD4-Positive T-Lymphocytes(immunology); CD8-Positive T-Lymphocytes(immunology); Epitopes; Evolution, Molecular; Hepacivirus(genetics; immunology; physiology); Hepatitis C(immunology; virology); Immunologic Memory; Liver(immunology); Major Histocompatibility Complex; Molecular Sequence Data; Mutation; Pan troglodytes; T-Lymphocyte Subsets(immunology); Time Factors; Viral Core Proteins(chemistry; genetics; immunology); Viral Nonstructural Proteins(chemistry; genetics; immunology); Viremia; Virus Replication
Curation Last Updated:2015-01-27 18:36:19