Epitopes described in "HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes."

Article Authors:Gabriella Pietra; Chiara Romagnani; Paola Mazzarino; Michela Falco; Enrico Millo; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Article Title:HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes.
Reference Detail
Reference ID:1004613
Abstract:HLA-E-restricted T cell receptor alphabeta+ CD8+ cytolytic T lymphocytes (CTLs) exist as monoclonal expansions in the peripheral blood of some individuals. Here, we show that they recognize, with high avidity, peptides derived from the UL40 protein of different human cytomegalovirus (CMV) strains. Recognition results in the induction of cytotoxicity, IFN-gamma production and cell proliferation. Autologous cells pulsed with CMV-derived peptides become susceptible to lysis by HLA-E-restricted CTLs and induce their proliferation. The high avidity for CMV-derived peptides may explain how these cells are generated in vivo and suggest their possible role in the host defenses against CMV, a virus that evolved various mechanisms to down-regulate classical HLA class I molecules, thus escaping detection by conventional CTLs.
Affiliations:Istituto Giannina Gaslini, 16147 Genova, Italy.
Reference Type:Literature
PubMed ID:12960383
Journal:Proc Natl Acad Sci U S A
Journal Volume:100
Article Pages:10896-901
Journal ISSN:0027-8424
Article Chemical List:DNA Primers;HLA Antigens;HLA-E antigen;Histocompatibility Antigens Class I
Article MeSH List:Amino Acid Sequence; Base Sequence; CD8-Positive T-Lymphocytes(immunology); Clone Cells; Cytomegalovirus(immunology); DNA Primers; Flow Cytometry; HLA Antigens(immunology); Histocompatibility Antigens Class I(immunology); Humans; Molecular Sequence Data
Curation Last Updated:2015-06-05 00:53:01