Epitopes described in "Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever."

Article Authors:Juthathip Mongkolsapaya; Wanwisa Dejnirattisai; Xiao-ning Xu; Sirijitt Vasanawathana; Nattaya Tangthawornchaikul; Aroonrung Chairunsri; Siraporn Sawasdivorn; Thaneeya Duangchinda; Tao Dong; Sarah Rowland-Jones; Pa-thai Yenchitsomanus; Andrew McMichael; Prida Malasit; Gavin Screaton
Article Title:Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
Reference Detail
Reference ID:1001414
Abstract:Dengue virus presents a growing threat to public health in the developing world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfection with a second serotype. We have studied dengue virus-specific T-cell responses in Thai children. During acute infection, few dengue-responsive CD8+ T cells were recovered; most of those present showed an activated phenotype and were undergoing programmed cell death. Many dengue-specific T cells were of low affinity for the infecting virus and showed higher affinity for other, probably previously encountered strains. Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T-cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
Affiliations:MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Reference Type:Literature
PubMed ID:12808447
Journal:Nat Med
Journal Volume:9
Article Pages:921-7
Journal ISSN:1078-8956
Article Chemical List:Epitopes;HLA-A Antigens;HLA-A11
Article MeSH List:Apoptosis(immunology; physiology); CD8-Positive T-Lymphocytes(immunology; virology); Child; Dengue Hemorrhagic Fever(immunology; virology); Dengue Virus(classification; immunology); Epitopes(immunology); Genetic Variation; HLA-A Antigens(immunology); Humans; T-Lymphocytes(immunology; virology); Thailand
Curation Last Updated:2011-10-24 21:00:47