Epitopes described in "Molecular analysis of the association of HLA-B53 and resistance to severe malaria."

Article Authors:A V Hill; J Elvin; A C Willis; M Aidoo; C E Allsopp; F M Gotch; X M Gao; M Takiguchi; B M Greenwood; A R Townsend
Article Title:Molecular analysis of the association of HLA-B53 and resistance to severe malaria.
Reference Detail
Reference ID:315001
Abstract:The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.
Affiliations:Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK.
Reference Type:Literature
PubMed ID:1280333
Journal Volume:360
Article Pages:434-9
Journal ISSN:1476-4687
Article Chemical List:Antigens, Protozoan;Epitopes;HLA Antigens;HLA-B53 antigen;Oligodeoxyribonucleotides;Vaccines;liver stage-specific antigen, Plasmodium
Article MeSH List:Amino Acid Sequence; Animals; Antigens, Protozoan(genetics; immunology); B-Lymphocytes(immunology); Base Sequence; Cell Line; Epitopes(analysis; immunology); Genetic Variation; HLA Antigens(genetics; immunology; isolation & purification); Histocompatibility Testing; Humans; Immunity, Innate; Liver(immunology; parasitology); Malaria(immunology); Malaria, Falciparum(immunology); Molecular Sequence Data; Oligodeoxyribonucleotides; Plasmodium falciparum(immunology); Polymerase Chain Reaction; T-Lymphocytes, Cytotoxic(immunology); Vaccines
Article Comments:Data originally imported from the Database of Functional Molecular Immunology, FIMM (http://sdmc.lit.org.sg:8080/fimm/) and from the HLA Ligand Database (http://hlaligand.ouhsc.edu/)
Curation Last Updated:2016-01-06 18:18:57