Epitopes described in "Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia."

Reference
Article Authors:Kamal M Khanna; Robert H Bonneau; Paul R Kinchington; Robert L Hendricks
Article Title:Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia.
Reference Detail
Reference ID:1025844
Abstract:This study challenges the concept that herpes simplex virus type 1 (HSV-1) latency represents a silent infection that is ignored by the host immune system, and suggests antigen-directed retention of memory CD8(+) T cells. CD8(+) T cells specific for the immunodominant gB(498-505) HSV-1 epitope are selectively retained in the ophthalmic branch of the latently infected trigeminal ganglion, where they acquire and maintain an activation phenotype and the capacity to produce IFN-gamma. Some CD8(+) T cells showed TCR polarization to junctions with neurons. A gB(498-505) peptide-specific CD8(+) T cell clone can block HSV-1 reactivation from latency in ex vivo trigeminal ganglion cultures. We conclude that CD8(+) T cells provide active surveillance of HSV-1 gene expression in latently infected sensory neurons.
Date:2003
Reference Type:Literature
PubMed ID:12753737
Journal:Immunity
Journal Volume:18
Article Pages:593-603
Journal ISSN:1074-7613
Article Chemical List:Epitopes
Article MeSH List:Animals; CD8-Positive T-Lymphocytes(immunology); Epitopes(immunology); Herpes Simplex(immunology); Immunologic Memory(immunology); Mice; Mice, Inbred C57BL; Simplexvirus(immunology); Trigeminal Ganglion(immunology; virology); Virus Latency(immunology)
Curation Last Updated:2014-04-01 22:06:09