Epitopes described in "H2-M3-restricted memory T cells: persistence and activation without expansion."

Reference
Article Authors:Kristen M Kerksiek; Alexander Ploss; Ingrid Leiner; Dirk H Busch; Eric G Pamer
Article Title:H2-M3-restricted memory T cells: persistence and activation without expansion.
Reference Detail
Reference ID:779
Abstract:H2-M3-restricted T cells respond more rapidly to primary Listeria monocytogenes infection than conventional MHC class Ia-restricted T cells. Reinfection with L. monocytogenes, while inducing explosive proliferation of H2-K(d)-restricted T cells, does not stimulate significant expansion of H2-M3-restricted CTL. These disparate responses to reinfection are apparent within 5 days of primary L. monocytogenes infection. However, H2-M3-restricted memory T cells are generated, and are indistinguishable from classically restricted T cells in terms of cell surface memory markers and longevity. Early responses of H2-M3- and H2-K(d)-restricted memory T cells to reinfection are similar, with increases in size and expression of activation markers. Interestingly, priming of H2-M3-restricted T cells with an L. monocytogenes-derived N-formyl peptide plus anti-CD40 generates memory T cells that expand upon re-exposure to Ag during L. monocytogenes infection. Our data indicate that disparate H2-M3- and MHC class Ia-restricted memory T cell responses reflect intrinsic differences between these T cell populations. Although distinct proliferative programs appear to be hardwired in these populations during primary L. monocytogenes infection, under different inflammatory circumstances M3-restricted T cell populations can maintain the ability to expand upon re-exposure to Ag.
Affiliations:Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Date:2003
Reference Type:Literature
PubMed ID:12574352
Journal:J Immunol
Journal Volume:170
Article Pages:1862-9
Journal ISSN:0022-1767
Article Chemical List:Antigens, Bacterial;Bacterial Toxins;Biological Markers;H-2 Antigens;H-2K(K) antigen;H2-M3 antigen;Heat-Shock Proteins;Hemolysin Proteins;Histocompatibility Antigens Class I;Peptide Fragments;hlyA protein, Listeria monocytogenes
Article MeSH List:Animals; Antigens, Bacterial(immunology); Bacterial Toxins; Biological Markers(analysis); Cell Division(genetics; immunology); Cell Survival(genetics; immunology); Female; H-2 Antigens(analysis); Heat-Shock Proteins(immunology); Hemolysin Proteins; Histocompatibility Antigens Class I(analysis; immunology); Immunization; Immunization, Secondary; Immunologic Memory(genetics); Listeria monocytogenes(immunology); Listeriosis(immunology; microbiology); Lymphocyte Activation(genetics); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments(immunology); T-Lymphocyte Subsets(cytology; immunology; metabolism; microbiology); T-Lymphocytes, Cytotoxic(cytology; immunology; metabolism; microbiology)
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