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| Article Authors: | Georg Lautscham; Tracey Haigh; Sabine Mayrhofer; Graham Taylor; Debbie Croom-Carter; Alison Leese; Stephan Gadola; Vincenzo Cerundolo; Alan Rickinson; Neil Blake |
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| Article Title: | Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2. |
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| Reference ID: | 1004645 |
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| Abstract: | We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation. |
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| Affiliations: | Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK. |
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| Date: | 2003 |
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| Reference Type: | Literature |
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| PubMed ID: | 12552018 |
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| Journal: | J Virol |
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| Journal Volume: | 77 |
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| Article Pages: | 2757-61 |
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| Journal ISSN: | 1098-5514 |
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| Article Chemical List: | ATP-Binding Cassette Transporters;Epitopes, T-Lymphocyte;HLA-A2 Antigen;TAP1 protein, human;LMP-2 protein;Cysteine Endopeptidases |
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| Article MeSH List: | ATP-Binding Cassette Transporters(metabolism); CD8-Positive T-Lymphocytes(immunology); Cysteine Endopeptidases(metabolism); Epitopes, T-Lymphocyte(immunology); HLA-A2 Antigen(metabolism); Herpesvirus 4, Human(immunology); Humans; Leukocytes, Mononuclear(immunology); Lymphocyte Activation |
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| Curation Last Updated: | 2013-05-28 20:47:38 |
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