Epitopes described in "Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2."

Reference
Article Authors:Georg Lautscham; Tracey Haigh; Sabine Mayrhofer; Graham Taylor; Debbie Croom-Carter; Alison Leese; Stephan Gadola; Vincenzo Cerundolo; Alan Rickinson; Neil Blake
Article Title:Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.
Reference Detail
Reference ID:1004645
Abstract:We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
Date:2003
Reference Type:Literature
PubMed ID:12552018
Journal:J Virol
Journal Volume:77
Article Pages:2757-61
Journal ISSN:1098-5514
Article Chemical List:Epitopes, T-Lymphocyte;HLA-A2 Antigen;TAP1 protein, human;LMP-2 protein;Cysteine Endopeptidases
Article MeSH List:ATP-Binding Cassette Transporters(metabolism); CD8-Positive T-Lymphocytes(immunology); Cysteine Endopeptidases(metabolism); Epitopes, T-Lymphocyte(immunology); HLA-A2 Antigen(metabolism); Herpesvirus 4, Human(immunology); Humans; Leukocytes, Mononuclear(immunology); Lymphocyte Activation
Curation Last Updated:2014-05-15 20:33:19