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| Article Authors: | Minako Oshima; Philip Deitiker; Tetsuo Ashizawa; M Zouhair Atassi |
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| Article Title: | Vaccination with a MHC class II peptide attenuates cellular and humoral responses against tAChR and suppresses clinical EAMG. |
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| Reference ID: | 1016896 |
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| Abstract: | An animal model of myasthenia gravis (MG), termed experimental autoimmune MG (EAMG), can be induced in C57BL/6 (B6, H-2b) mice by immunization with Torpedo californica acetylcholine receptor (tAChR). We have investigated the effect of vaccination with MHC class II peptide I-A beta(b)62-76 on clinical EAMG and on T cell and antibody (Ab) responses against tAChR. B6 mice were vaccinated with the peptide (25 microg/mouse) four times prior to two injections with tAChR. The incidence of clinical EAMG in vaccinated mice was 14% (3 out of 22 mice) compared to 48% (17 out of 35 mice) in control non-vaccinated or PBS-immunized mice. The T cells of the vaccinated group showed lower proliferative responses to tAChR and to T-cell epitope-containing tAChR alpha-chain peptides than the T cells of controls. In addition, the Ab responses in the vaccinated group was also lower against tAChR and some of the B-cell epitope-containing tAChR alpha-chain peptides. |
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| Affiliations: | Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. moshima@bcm.tmc.edu |
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| Date: | 2002 |
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| Reference Type: | Literature |
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| PubMed ID: | 12389643 |
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| Journal: | Autoimmunity |
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| Journal Volume: | 35 |
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| Article Pages: | 183-90 |
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| Journal ISSN: | 0891-6934 |
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| Article Chemical List: | Histocompatibility Antigens Class II;Peptide Fragments;Receptors, Cholinergic |
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| Article MeSH List: | Amino Acid Sequence; Animals; Antibody Formation; Histocompatibility Antigens Class II(immunology); Lymphocyte Activation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Myasthenia Gravis, Autoimmune, Experimental(prevention & control); Peptide Fragments(immunology); Receptors, Cholinergic(immunology); T-Lymphocytes(immunology); Torpedo; Vaccination |
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| Curation Last Updated: | 2013-05-28 21:55:16 |
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