Epitopes described in "Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages."

Reference
Article Authors:Julius C R Hafalla; Gen-ichiro Sano; Luzia H Carvalho; Alexandre Morrot; Fidel Zavala
Article Title:Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.
Reference Detail
Reference ID:1025867
Abstract:Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of antigen-specific CD8(+) T cells, is of short duration, with maximum T cell activation occurring within the first 8 h after immunization and lasting approximately 48 h. Although the magnitude of the CD8(+) T cell response closely correlates with the number of parasites used for immunization, increasing the time of antigen presentation by daily immunizations does not enhance the magnitude of this response. Thus, once a primary clonal burst is established, the CD8(+) T cell response becomes refractory or unresponsive to further antigenic stimulation. These findings strongly suggest that the most efficient strategy for the induction of primary CD8(+) T cell responses is the delivery of a maximal amount of antigen in a single dose, thereby ensuring a clonal burst that involves the largest number of precursors to become memory cells.
Date:2002
Reference Type:Literature
PubMed ID:12185251
Journal:Proc Natl Acad Sci U S A
Journal Volume:99
Article Pages:11819-24
Journal ISSN:1091-6490
Article Chemical List:Antigens;Antimalarials;Primaquine
Article MeSH List:Amino Acid Sequence; Animals; Antigens(biosynthesis); Antimalarials(pharmacology); CD8-Positive T-Lymphocytes(immunology); Enzyme-Linked Immunosorbent Assay; Female; Liver(parasitology); Lymphocyte Activation; Mice; Plasmodium(immunology); Primaquine(pharmacology)
Article Comments:ErratumIn(Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611 )
Curation Last Updated:2014-10-03 22:54:19