Epitopes described in "T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens."

Article Authors:Michael A Brehm; Amelia K Pinto; Keith A Daniels; Jonathan P Schneck; Raymond M Welsh; Liisa K Selin
Article Title:T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens.
Reference Detail
Reference ID:1253
Abstract:We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8(+) T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8(+) T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.
Affiliations:Department of Pathology and Progranm in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Reference Type:Literature
PubMed ID:12055626
Journal:Nat Immunol
Journal Volume:3
Article Pages:627-34
Journal ISSN:1529-2908
Article Chemical List:Antigens, Viral;Epitopes, T-Lymphocyte;H-2 Antigens;H-2Kb protein, mouse;Immunodominant Epitopes;Nucleoproteins;Peptides;Viral Proteins
Article MeSH List:Animals; Antigens, Viral(immunology); CD8-Positive T-Lymphocytes(immunology); Cell Line; Cricetinae; Cross Reactions; Epitopes, T-Lymphocyte(immunology); H-2 Antigens(immunology); Immunodominant Epitopes(immunology); Immunologic Memory(immunology); Lymphocytic choriomeningitis virus(immunology); Male; Mice; Mice, Inbred C57BL; Nucleoproteins(immunology); Peptides(immunology); Pichinde virus(immunology); Viral Proteins(immunology)
Curation Last Updated:2015-07-30 20:02:41