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| Article Authors: | Michael A Brehm; Amelia K Pinto; Keith A Daniels; Jonathan P Schneck; Raymond M Welsh; Liisa K Selin |
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| Article Title: | T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. |
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| Reference ID: | 1253 |
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| Abstract: | We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8(+) T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8(+) T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology. |
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| Affiliations: | Department of Pathology and Progranm in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA. |
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| Date: | 2002 |
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| Reference Type: | Literature |
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| PubMed ID: | 12055626 |
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| Journal: | Nat Immunol |
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| Journal Volume: | 3 |
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| Article Pages: | 627-34 |
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| Journal ISSN: | 1529-2908 |
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| Article Chemical List: | Antigens, Viral;Epitopes, T-Lymphocyte;H-2 Antigens;H-2Kb protein, mouse;Immunodominant Epitopes;Nucleoproteins;Peptides;Viral Proteins |
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| Article MeSH List: | Animals; Antigens, Viral(immunology); CD8-Positive T-Lymphocytes(immunology); Cell Line; Cricetinae; Cross Reactions; Epitopes, T-Lymphocyte(immunology); H-2 Antigens(immunology); Immunodominant Epitopes(immunology); Immunologic Memory(immunology); Lymphocytic choriomeningitis virus(immunology); Male; Mice; Mice, Inbred C57BL; Nucleoproteins(immunology); Peptides(immunology); Pichinde virus(immunology); Viral Proteins(immunology) |
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| Curation Last Updated: | 2011-10-24 20:19:44 |
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