Epitopes described in "Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease."

Article Authors:Ronald B DeMattos; Kelly R Bales; David J Cummins; Steven M Paul; David M Holtzman
Article Title:Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.
Reference Detail
Reference ID:1007080
Abstract:The deposition of amyloid-beta (Abeta) peptides into amyloid plaques precedes the cognitive dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative of brain amyloid burden could be useful for identifying individuals at high risk for developing AD. As in AD in humans, baseline plasma Abeta levels in a transgenic mouse model of AD did not correlate with brain amyloid burden. However, after peripheral administration of a monoclonal antibody to Abeta (m266), we observed a rapid increase in plasma Abeta and the magnitude of this increase was highly correlated with amyloid burden in the hippocampus and cortex. This method may be useful for quantifying brain amyloid burden in patients at risk for or those who have been diagnosed with AD.
Affiliations:Center for the Study of Nervous System Injury, Alzheimer's Disease Research Center, Department of Neurology, Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA.
Reference Type:Literature
PubMed ID:11910111
Journal Volume:295
Article Pages:2264-7
Journal ISSN:1095-9203
Article Chemical List:Amyloid beta-Peptides;Antibodies, Monoclonal
Article MeSH List:Alzheimer Disease(blood; genetics; metabolism; pathology); Amino Acid Substitution; Amyloid beta-Peptides(blood; chemistry; genetics; metabolism); Amyloidosis(blood; genetics; metabolism; pathology); Animals; Antibodies, Monoclonal(immunology); Brain(metabolism; pathology); Cerebral Cortex(metabolism; pathology); Disease Models, Animal; Hippocampus(metabolism; pathology); Humans; Mice; Protein Transport; Solubility; Time Factors
Curation Last Updated:2014-10-03 20:54:35