Epitopes described in "IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages."

Reference
Article Authors:Luzia H Carvalho; Gen-Ichiro Sano; Julius C R Hafalla; Alexandre Morrot; Maria A Curotto de Lafaille; Fidel Zavala
Article Title:IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.
Reference Detail
Reference ID:1026007
Abstract:CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days after immunization. However, this response fails to develop further and is reduced by more than 90%, compared to that observed in the presence of CD4+ T cells. We report here that interleukin-4 (IL-4) secreted by CD4+ T cells is essential to the full development of this CD8+ T cell response. This is the first demonstration that IL-4 is a mediator of CD4/CD8 cross-talk leading to the development of immunity against an infectious pathogen.
Affiliations:Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, USA.
Date:2002
Reference Type:Literature
PubMed ID:11821901
Journal:Nat Med
Journal Volume:8
Article Pages:166-70
Journal ISSN:1078-8956
Article Chemical List:Antigens, CD4;Interleukin-4
Article MeSH List:Animals; Antigens, CD4(immunology); CD4-Positive T-Lymphocytes(cytology; immunology); CD8-Positive T-Lymphocytes(cytology; immunology); Cell Differentiation(immunology); Hepatocytes(immunology); Interleukin-4(secretion); Malaria(immunology); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Plasmodium yoelii
Curation Last Updated:2014-10-03 22:54:48