Epitopes described in "Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes."

Reference
Article Authors:Sarah C Gilbert; Jörg Schneider; Carolyn M Hannan; Jiang Ting Hu; Magdalena Plebanski; Robert Sinden; Adrian V S Hill
Article Title:Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes.
Reference Detail
Reference ID:1338
Abstract:Recombinant replication-defective adenovirus expressing the CS gene from Plasmodium berghei (Ad-PbCS) was found to induce a strong CD8(+) T cell response after intra-dermal or -muscular immunisation. Boosting of an adenovirus-primed immune response with the replication-impaired poxvirus, modified vaccinia virus Ankara (MVA) led to enhanced immunogenicity and substantial protective efficacy. The recombinant adenoviral vaccine was capable of boosting to protective levels a CD8(+) T cell response primed by either a plasmid DNA vaccine, a recombinant Ty virus-like particle vaccine or recombinant MVA each expressing the same epitope or antigen. Complete protective efficacy after intradermal immunisation was observed with the adenovirus prime-MVA boost regime. This study identifies recombinant replication-defective adenovirus as an alternative to recombinant replication-defective poxviruses as boosting agents for the induction of strong protective CD8(+) T cell responses.
Affiliations:Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK. sarah.gilbert@well.ox.ac.uk
Date:2002
Reference Type:Literature
PubMed ID:11803063
Journal:Vaccine
Journal Volume:20
Article Pages:1039-45
Journal ISSN:0264-410X
Article Chemical List:Malaria Vaccines;Vaccines, DNA;Vaccines, Synthetic
Article MeSH List:Adenoviridae(genetics); Animals; CD8-Positive T-Lymphocytes(immunology); Female; Immunization, Secondary; Malaria(prevention & control); Malaria Vaccines(immunology); Mice; Mice, Inbred BALB C; Vaccines, DNA(immunology); Vaccines, Synthetic(immunology); Vaccinia virus(genetics)
Curation Last Updated:2014-10-03 19:39:17