Epitopes described in "Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein."

Reference
Article Authors:C Brander; P O'Connor; T Suscovich; N G Jones; Y Lee; D Kedes; D Ganem; J Martin; D Osmond; S Southwood; A Sette; B D Walker; D T Scadden
Article Title:Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
Reference Detail
Reference ID:200132
Abstract:Cytotoxic T lymphocytes (CTL) recognize and kill virus-infected cells and contribute to immunologic control of viral replication. For many herpesviruses (e.g., Epstein-Barr and cytomegalovirus), virus-specific CTL responses can be readily detected in infected persons, but CTL responses against Kaposi's sarcoma-associated herpesvirus (KSHV) appear to be weak and remain poorly characterized. Using a human leukocyte antigen (HLA) binding motif-based epitope prediction algorithm, we identified 37 HLA-A*0201 binding peptides from 8 KSHV open-reading frames (ORFs). After in vitro stimulation of peripheral blood mononuclear cells from KSHV-infected persons, CTL responses against 1 peptide in the KSHV kaposin protein (ORF K12) were detected in 2 HLA-A*0201-positive subjects. The optimal CTL epitope was identified by HLA restriction analysis and peptide titration assays. These data describe a latent phase viral gene product targeted by CTL that may be relevant for KSHV immunopathogenesis.
Affiliations:AIDS Research Center and Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Date:2001
Reference Type:Literature
PubMed ID:11424007
Journal:J Infect Dis
Journal Volume:184
Article Pages:119-26
Journal ISSN:1537-6613
Article Chemical List:Epitopes;HLA-A Antigens;Viral Proteins;kaposin B protein, Human herpesvirus 8
Article MeSH List:Acquired Immunodeficiency Syndrome(immunology); Epitopes; Gene Expression Regulation, Viral; HLA-A Antigens(immunology); Herpesvirus 8, Human(immunology); Humans; T-Lymphocytes, Cytotoxic(immunology); Viral Proteins(immunology)
Article Comments:Data originally imported from the HLA Ligand Database (http://hlaligand.ouhsc.edu/)
Curation Last Updated:2014-10-03 19:42:40