Epitopes described in "Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin."

Reference
Article Authors:M Christodoulides; E Rattue; J E Heckels
Article Title:Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin.
Reference Detail
Reference ID:1008917
Abstract:A variety of adjuvants with the potential for use with experimental human vaccines were used for immunisation of mice, in an attempt to augment the humoral immune response to a multiple antigen peptide (MAP) containing a protective epitope from the sero-subtype specific class 1 porin protein of Neisseria meningitidis, in tandem with a Th-cell epitope. Surface plasmon resonance showed that combinations of the immunomodulators pluronic block co-polymer, muramyl dipeptide and monophosphoryl lipid A (MPL), increased the magnitude and avidity of the immune response in comparison with both Al(OH)3 and Freund-type adjuvants. In addition, the incorporation of MPL was essential for the induction of a broad distribution of antibody isotypes. The antibodies induced recognised the native protein in meningococcal outer membranes in a subtype-specific manner. The formulations containing these multiple immunomodulators which have already been used in human phase I/II trials with experimental vaccines, are candidates for inclusion in future human vaccines based on synthetic peptides containing defined, protective epitopes.
Affiliations:Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK. mc4@soton.ac.uk
Date:1999
Reference Type:Literature
PubMed ID:10501243
Journal:Vaccine
Journal Volume:18
Article Pages:131-9
Journal ISSN:0264-410X
Article Chemical List:Adjuvants, Immunologic;Antibodies, Bacterial;Bacterial Outer Membrane Proteins;Bacterial Vaccines;Epitopes;Immune Sera;Porins
Article MeSH List:Adjuvants, Immunologic(pharmacology ); Animals; Antibodies, Bacterial(blood; immunology ); Bacterial Outer Membrane Proteins(immunology ); Bacterial Vaccines(immunology ); Epitopes; Immune Sera(immunology ); Mice; Mice, Inbred BALB C; Neisseria meningitidis(immunology ); Porins(immunology )
Curation Last Updated:2014-07-16 21:37:30