Epitopes described in "Chlamydia infections and heart disease linked through antigenic mimicry."

Article Authors:K Bachmaier; N Neu; L M de la Maza; S Pal; A Hessel; J M Penninger
Article Title:Chlamydia infections and heart disease linked through antigenic mimicry.
Reference Detail
Reference ID:1001187
Abstract:Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein.
Reference Type:Literature
PubMed ID:10037605
Journal Volume:283
Article Pages:1335-9
Journal ISSN:1095-9203
Article Chemical List:Antigens, Bacterial;Autoantibodies;Bacterial Outer Membrane Proteins;Oligodeoxyribonucleotides;Myosin Heavy Chains
Article MeSH List:Adoptive Transfer; Amino Acid Sequence; Animals; Antigens, Bacterial(chemistry; immunology); Autoantibodies(biosynthesis); Autoimmune Diseases(immunology; microbiology; pathology); B-Lymphocytes(immunology); Bacterial Outer Membrane Proteins(chemistry; immunology); CD4-Positive T-Lymphocytes(immunology); Chlamydia(immunology); Chlamydia Infections(complications; immunology); Chlamydia trachomatis(immunology); CpG Islands; Humans; Immunization; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Molecular Mimicry; Molecular Sequence Data; Myocarditis(immunology; microbiology; pathology); Myocardium(immunology; pathology); Myosin Heavy Chains(chemistry; immunology); Oligodeoxyribonucleotides(immunology); Sequence Homology, Amino Acid
Curation Last Updated:2015-07-30 20:10:18