EPITOPE SUMMARY
LLFGYPVYV is a linear peptidic epitope (epitope ID
37257
) studied as part of Protein Tax-1 (UniProt:P14079) from Primate T-lymphotropic virus 1. This epitope has been studied for immune reactivity in
96
publication(s), tested in
387
T cell assays,
7
B cell assays,
39
MHC ligand assays and has 3D structure(s)
1AO7
,
6UZ1
,
4FTV
,
1DUZ
,
1BD2
,
2AV1
,
2AV7
,
1IM3
,
4E5X
,
3IXA
,
1HHK
and
5IRO
.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
39
MHC moleculePositive / All
HLA-A*02:01
27
/
27
HLA-A*02:01 K66A mutant
3
/
3
HLA-A*02:01 K66A, E63Q mutant
3
/
3
HLA-A2
3
/
3
HLA-A*02:01 A150P mutant
1
/
1
HLA-A*02:02
1
/
1
HLA-A*02:05
1
/
1
B Cell Assay(s)
7
Assay TypePositive / All
qualitative binding
7
/
7
T Cell Assay(s)
387
Assay TypePositive / All
dissociation constant KD
65
/
66
cytotoxicity
57
/
60
IFNg release
54
/
55
qualitative binding
51
/
53
off rate
48
/
48
on rate
48
/
48
proliferation
14
/
14
CCL4/MIP-1b release
11
/
12
IL-2 release
3
/
6
3D structure
4
/
4
degranulation
3
/
3
IL-4 release
3
/
3
CCL3/MIP-1a release
2
/
2
decreased disease
2
/
2
granzyme B release
2
/
2
T cell- APC binding
2
/
2
activation
1
/
2
pathogen burden after challenge
1
/
1
TNF release
1
/
1
TNFa release
1
/
1
tolerance
1
/
1
perforin release
0
/
1
EXTERNAL RESOURCES
ResourceLink
IEDB-AR: MHC-I Processing
Predict MHC class I processing
IEDB-AR: MHC-I
Predict MHC class I binding affinity
IEDB-AR: B cell scales
Predict B cell epitopes